abstract：:Neonatal mouse hearts fully regenerate after ventricular resection similar to adult zebrafish. We established cryoinjury models to determine if different types and varying degrees of severity in cardiac injuries trigger different responses in neonatal mouse hearts. In contrast to ventricular resection, neonatal mouse ...

journal_title：Developmental biology

authors： Darehzereshki A,Rubin N,Gamba L,Kim J,Fraser J,Huang Y,Billings J,Mohammadzadeh R,Wood J,Warburton D,Kaartinen V,Lien CL

更新日期：2015-03-01 00:00:00

abstract：:The mammalian thalamus is an essential diencephalic derivative that plays unique roles in processing and relaying sensory and motor information to and from the cerebral cortex. The profile of transcription factors and lineage tracing experiments revealed a spatiotemporal relationship between diencephalic progenitor do...

journal_title：Developmental biology

authors： Song H,Lee B,Pyun D,Guimera J,Son Y,Yoon J,Baek K,Wurst W,Jeong Y

更新日期：2015-02-15 00:00:00

abstract：:Malpighian tubules are the osmoregulatory and detoxifying organs of Drosophila and its proper development is critical for the survival of the organism. They are made up of two major cell types, the ectodermal principal cells and mesodermal stellate cells. The principal and stellate cells are structurally and physiolog...

journal_title：Developmental biology

authors： Gautam NK,Verma P,Tapadia MG

更新日期：2015-02-15 00:00:00

abstract：:The ability to express exogenous reporter genes in intact, externally developing embryos, such as Xenopus, is a powerful tool for characterizing the activity of cis-regulatory gene elements during development. Although methods exist for generating transgenic Xenopus lines, more simplified methods for use with F0 anima...

journal_title：Developmental biology

authors： Wang C,Szaro BG

更新日期：2015-02-01 00:00:00

abstract：:The respective role of Pax2 and Pax8 in early kidney development in vertebrates is poorly understood. In this report, we have studied the roles of Pax8 and Pax2 in Xenopus pronephros development using a loss-of-function approach. Our results highlight a differential requirement of these two transcription factors for p...

journal_title：Developmental biology

authors： Buisson I,Le Bouffant R,Futel M,Riou JF,Umbhauer M

更新日期：2015-01-15 00:00:00

abstract：:Huntington disease (HD) is an adult-onset neurodegenerative disease characterized by motor, cognitive, and psychiatric symptoms that is caused by a CAG expansion in the HTT gene. Palmitoylation is the addition of saturated fatty acids to proteins by DHHC palmitoylacyl transferases. HTT is palmitoylated by huntingtin i...

journal_title：Developmental biology

authors： Sanders SS,Hou J,Sutton LM,Garside VC,Mui KK,Singaraja RR,Hayden MR,Hoodless PA

更新日期：2015-01-15 00:00:00

abstract：UNLABELLED:Notch signaling plays an acknowledged role in bile-duct development, but its involvement in cholangiocyte-fate determination remains incompletely understood. We investigated the effects of early Notch2 deletion in Notch2(fl/fl)/Alfp-Cre(tg/-) ("Notch2-cKO") and Notch2(fl/fl)/Alfp-Cre(-/-) ("control") mice. F...

journal_title：Developmental biology

authors： Falix FA,Weeda VB,Labruyere WT,Poncy A,de Waart DR,Hakvoort TB,Lemaigre F,Gaemers IC,Aronson DC,Lamers WH

更新日期：2014-12-15 00:00:00

abstract：:TGF-beta (TGFβ) family mediated Smad signaling is involved in mesoderm and endoderm specifications, left-right asymmetry formation and neural tube development. The TGFβ1/2/3 and Activin/Nodal signal transduction cascades culminate with activation of SMAD2 and/or SMAD3 transcription factors and their overactivation are...

journal_title：Developmental biology

authors： Casari A,Schiavone M,Facchinello N,Vettori A,Meyer D,Tiso N,Moro E,Argenton F

更新日期：2014-12-01 00:00:00

abstract：:To feed or breathe, the oral opening must connect with the gut. The foregut and oral tissues converge at the primary mouth, forming the buccopharyngeal membrane (BPM), a bilayer epithelium. Failure to form the opening between gut and mouth has significant ramifications, and many craniofacial disorders have been associ...

journal_title：Developmental biology

authors： Tabler JM,Bolger TG,Wallingford J,Liu KJ

更新日期：2014-12-01 00:00:00

abstract：:Integrin α5-null embryos die in mid-gestation from severe defects in cardiovascular morphogenesis, which stem from defective development of the neural crest, heart and vasculature. To investigate the role of integrin α5β1 in cardiovascular development, we used the Mesp1(Cre) knock-in strain of mice to ablate integrin ...

journal_title：Developmental biology

authors： Liang D,Wang X,Mittal A,Dhiman S,Hou SY,Degenhardt K,Astrof S

更新日期：2014-11-15 00:00:00

abstract：:FOG-2 is a multi-zinc finger protein that binds the transcriptional activator GATA4 and modulates GATA4-mediated regulation of target genes during heart development. Our previous work has demonstrated that the Nucleosome Remodeling and Deacetylase (NuRD) complex physically interacts with FOG-2 and is necessary for FOG...

journal_title：Developmental biology

authors： Garnatz AS,Gao Z,Broman M,Martens S,Earley JU,Svensson EC

更新日期：2014-11-01 00:00:00

abstract：:Epithelial sheet movement is an essential morphogenetic process during mouse embryonic eyelid closure in which Mitogen-Activated Protein 3 Kinase 1 (MAP3K1) and c-Jun play a critical role. Here we show that MAP3K1 associates with the cytoskeleton, activates Jun N-terminal kinase (JNK) and actin polymerization, and pro...

journal_title：Developmental biology

authors： Meng Q,Mongan M,Wang J,Tang X,Zhang J,Kao W,Xia Y

更新日期：2014-11-01 00:00:00

abstract：:FgfrL1, which interacts with Fgf ligands and heparin, is a member of the fibroblast growth factor receptor (Fgfr) family. FgfrL1-deficient mice show two significant alterations when compared to wildtype mice: They die at birth due to a malformed diaphragm and they lack metanephric kidneys. Utilizing gene arrays, qPCR ...

journal_title：Developmental biology

authors： Amann R,Wyder S,Slavotinek AM,Trueb B

更新日期：2014-10-15 00:00:00

abstract：:Specification of the trophectoderm (TE) and inner cell mass (ICM) lineages in the mouse blastocyst correlates with cell position, as TE derives from outer cells whereas ICM from inner cells. Differences in position are reflected by cell polarization and Hippo signaling. Only in outer cells, the apical-basal cell polar...

journal_title：Developmental biology

authors： Kono K,Tamashiro DA,Alarcon VB

更新日期：2014-10-01 00:00:00

abstract：:Lumenogenesis of small seamless tubes occurs through intracellular membrane growth and directed vesicle fusion events. Within the Caenorhabditis elegans excretory cell, which forms seamless intracellular tubes (canals) that mediate osmoregulation, lumens grow in length and diameter when vesicles fuse with the expandin...

journal_title：Developmental biology

authors： Armenti ST,Chan E,Nance J

更新日期：2014-10-01 00:00:00

abstract：:Coordinated contraction of the heart is essential for survival and is regulated by the cardiac conduction system. Contraction of ventricular myocytes is controlled by the terminal part of the conduction system known as the Purkinje fiber network. Lineage analyses in chickens and mice have established that the Purkinje...

journal_title：Developmental biology

authors： Hua LL,Vedantham V,Barnes RM,Hu J,Robinson AS,Bressan M,Srivastava D,Black BL

更新日期：2014-09-15 00:00:00

abstract：:Myoblast fusion (a critical process by which muscles grow) occurs in a multi-step fashion that requires actin and membrane remodeling; but important questions remain regarding the spatial/temporal regulation of and interrelationship between these processes. We recently reported that the Rho-GAP, GRAF1, was particularl...

journal_title：Developmental biology

authors： Lenhart KC,Becherer AL,Li J,Xiao X,McNally EM,Mack CP,Taylor JM

更新日期：2014-09-15 00:00:00

abstract：:Mutations in the Bone Morphogenetic Protein (BMP) pathway are associated with a range of defects in skeletal formation. Genetic analysis of BMP signaling requirements is complicated by the presence of three partially redundant BMPs that are required for multiple stages of limb development. We generated an inducible al...

journal_title：Developmental biology

authors： Norrie JL,Lewandowski JP,Bouldin CM,Amarnath S,Li Q,Vokes MS,Ehrlich LIR,Harfe BD,Vokes SA

更新日期：2014-09-15 00:00:00

abstract：:The proper removal of superfluous neurons through apoptosis and subsequent phagocytosis is essential for normal development of the central nervous system (CNS). During Drosophila embryogenesis, a large number of apoptotic neurons are efficiently engulfed and degraded by phagocytic glia. Here we demonstrate that glial ...

journal_title：Developmental biology

authors： Shklyar B,Sellman Y,Shklover J,Mishnaevski K,Levy-Adam F,Kurant E

更新日期：2014-09-15 00:00:00

abstract：:Tubes with distinct shapes and sizes are critical for the proper function of many tubular organs. Here we describe a unique phenotype caused by the loss of a novel, evolutionarily-conserved, Drosophila Smad-like protein, Expansion. In expansion mutants, unicellular and intracellular tracheal branches develop bubble-li...

journal_title：Developmental biology

authors： Iordanou E,Chandran RR,Yang Y,Essak M,Blackstone N,Jiang L

更新日期：2014-09-01 00:00:00

abstract：:Tyrosinase is the rate-limiting enzyme for the production of melanin pigmentation. In the mouse and other animals, homozygous null mutations in the Tyrosinase gene (Tyr) result in the absence of pigmentation, i.e. albinism. Here we used the CRISPR/Cas9 system to generate mono- and bi-allelic null mutations in the Tyr ...

journal_title：Developmental biology

authors： Yen ST,Zhang M,Deng JM,Usman SJ,Smith CN,Parker-Thornburg J,Swinton PG,Martin JF,Behringer RR

更新日期：2014-09-01 00:00:00

abstract：:Chromatin regulators contribute to the developmental control of gene expression. In the nematode Caenorhabditis elegans, the roles of chromatin regulation in development have been explored in several contexts, including vulval differentiation. The synthetic multivulva (synMuv) genes are regulators of vulval developmen...

journal_title：Developmental biology

authors： Yücel D,Hoe M,Llamosas E,Kant S,Jamieson C,Young PA,Crossley M,Nicholas HR

更新日期：2014-08-15 00:00:00

abstract：:The early mouse embryo undertakes two types of cell division: symmetric that gives rise to the trophectoderm and then placenta or asymmetric that gives rise to inner cells that generate the embryo proper. Although cell division orientation is important, the mechanism regulating it has remained unclear. Here, we identi...

journal_title：Developmental biology

authors： Ajduk A,Biswas Shivhare S,Zernicka-Goetz M

更新日期：2014-08-15 00:00:00

abstract：:During Drosophila oogenesis, activation of Notch signaling in the follicular epithelium (FE) around stage 6 of oogenesis is essential for entry into the endocycle and a series of other changes such as cell differentiation and migration of subsets of the follicle cells. Notch induces the expression of zinc finger prote...

journal_title：Developmental biology

authors： Jia D,Tamori Y,Pyrowolakis G,Deng WM

更新日期：2014-08-01 00:00:00

abstract：:Congenital bony syngnathia, a rare but severe human birth defect, is characterized by bony fusion of the mandible to the maxilla. However, the genetic mechanisms underlying this birth defect are poorly understood, largely due to limitation of available animal models. Here we present evidence that transgenic expression...

journal_title：Developmental biology

authors： He F,Hu X,Xiong W,Li L,Lin L,Shen B,Yang L,Gu S,Zhang Y,Chen Y

更新日期：2014-07-15 00:00:00

abstract：:Continuous communication between cells is necessary for development of any multicellular organism and depends on the recognition of secreted signals. A wide range of molecules including proteins, peptides, amino acids, nucleic acids, steroids and polylketides are used as intercellular signals in plants and animals. Th...

journal_title：Developmental biology

authors： Loomis WF

更新日期：2014-07-01 00:00:00

abstract：:Tbx18 has been shown to be essential for ureteral development. However, it remains unclear whether it plays a direct role in kidney development. Here we addressed this by focusing on examining the pattern and contribution of Tbx18+ cells in the kidney and its role in kidney vascular development. Expression studies and...

journal_title：Developmental biology

authors： Xu J,Nie X,Cai X,Cai CL,Xu PX

更新日期：2014-07-01 00:00:00

abstract：:Sine Oculis (So), the founding member of the SIX family of homeobox transcription factors, binds to sequence specific DNA elements and regulates transcription of downstream target genes. It does so, in part, through the formation of distinct biochemical complexes with Eyes Absent (Eya) and Groucho (Gro). While these c...

journal_title：Developmental biology

authors： Anderson AM,Weasner BP,Weasner BM,Kumar JP

更新日期：2014-06-15 00:00:00

abstract：:Branching morphogenesis, the process by which cells or tissues generate tree-like networks that function to increase surface area or in contacting multiple targets, is a common developmental motif in multicellular organisms. We use Drosophila tracheal terminal cells, a component of the insect respiratory system, to in...

journal_title：Developmental biology

authors： Jones TA,Nikolova LS,Schjelderup A,Metzstein MM

更新日期：2014-06-01 00:00:00

abstract：:For both the intricate morphogenetic layout of the sensory cells in the ear and the elegantly radial arrangement of the sensory neurons in the nose, numerous signaling molecules and genetic determinants are required in concert to generate these specialized neuronal populations that help connect us to our environment. ...

journal_title：Developmental biology

authors： Maier EC,Saxena A,Alsina B,Bronner ME,Whitfield TT

更新日期：2014-05-01 00:00:00

abstract：:Xenopus laevis is among the few species that are capable of fully regenerating a lost lens de novo. This occurs upon removal of the lens, when secreted factors from the retina are permitted to reach the cornea epithelium and trigger it to form a new lens. Although many studies have investigated the retinal factors tha...

journal_title：Developmental biology

authors： Thomas AG,Henry JJ

更新日期：2014-02-15 00:00:00

abstract：:During organogenesis, Sonic hedgehog (Shh) possesses dual functions: Shh emanating from midline structures regulates the positioning of bilateral structures at early stages, whereas organ-specific Shh locally regulates organ morphogenesis at later stages. The mesonephros is a transient embryonic kidney in amniote, whe...

journal_title：Developmental biology

authors： Murashima A,Akita H,Okazawa M,Kishigami S,Nakagata N,Nishinakamura R,Yamada G

更新日期：2014-02-01 00:00:00

abstract：:Development of the mammalian external genitalia is controlled by a network of signaling molecules and transcription factors. Because FGF signaling plays a central role in this complicated morphogenetic process, we investigated the role of Sprouty genes, which are important intracellular modulators of FGF signaling, du...

journal_title：Developmental biology

authors： Ching ST,Cunha GR,Baskin LS,Basson MA,Klein OD

更新日期：2014-02-01 00:00:00

abstract：:Hox genes are well-known master regulators in developmental morphogenesis along the anteroposterior axis of animals. However, the molecular mechanisms by which Hox proteins regulate their target genes and determine cell fates are not fully understood. The silk gland of Bombyx mori is a tubular tissue divided into seve...

journal_title：Developmental biology

authors： Kimoto M,Tsubota T,Uchino K,Sezutsu H,Takiya S

更新日期：2014-02-01 00:00:00

abstract：:During early development, GATA factors have been shown to be important for key events of coronary vasculogenesis, including formation of the epicardium. Myocardial GATA factors are required for coronary vascular (CV) formation; however, the role of epicardial localized GATAs in this process has not been addressed. The...

journal_title：Developmental biology

authors： Kolander KD,Holtz ML,Cossette SM,Duncan SA,Misra RP

更新日期：2014-02-01 00:00:00

abstract：:Extraocular muscles (EOM) represent a unique muscle group that controls eye movements and originates from head mesoderm, while the more typically studied body and limb muscles are somite-derived. Aiming to investigate myogenic progenitors (satellite cells) in EOM versus limb and diaphragm of adult mice, we have been u...

journal_title：Developmental biology

authors： Stuelsatz P,Shearer A,Yablonka-Reuveni Z

更新日期：2014-01-15 00:00:00

abstract：:The development of the Drosophila leg is a good model to study processes of pattern formation, cell death and segmentation. Such processes require the coordinate activity of different genes and signaling pathways that progressively subdivide the leg territory into smaller domains. One of the main pathways needed for l...

journal_title：Developmental biology

authors： Guarner A,Manjón C,Edwards K,Steller H,Suzanne M,Sánchez-Herrero E

更新日期：2014-01-15 00:00:00

abstract：:Development and plasticity of synapses are brought about by a complex interplay between various signaling pathways. Typically, either changing the number of synapses or strengthening an existing synapse can lead to changes during synaptic plasticity. Altering the machinery that governs the exocytosis of synaptic vesic...

journal_title：Developmental biology

authors： Wairkar YP,Trivedi D,Natarajan R,Barnes K,Dolores L,Cho P

更新日期：2013-12-01 00:00:00

abstract：:etv2 is an endothelial-specific ETS transcription factor that is essential for vascular differentiation and morphogenesis in vertebrates. While recent data suggest that Etv2 is dynamically regulated during vascular development, little is known about the mechanisms involved in this process. Here, we find that etv2 tran...

journal_title：Developmental biology

authors： Moore JC,Sheppard-Tindell S,Shestopalov IA,Yamazoe S,Chen JK,Lawson ND

更新日期：2013-12-01 00:00:00

abstract：:In studies initially focused on roles of nonmuscle myosin IIA (NMIIA) in the developing mouse epidermis, we have discovered that a previously described cytokeratin 5 (K5)-Cre gene construct is expressed in early embryo development. Mice carrying floxed alleles of the nonmuscle myosin II heavy chain gene (NMHC IIA(flox...

journal_title：Developmental biology

authors： Crish J,Conti MA,Sakai T,Adelstein RS,Egelhoff TT

更新日期：2013-10-01 00:00:00